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At IMB, we explore the molecular biology of the nucleus with an overarching focus on gene regulation, epigenetics & genome stability

Johannes Gutenberg University (JGU) Mainz

Peter Baumann  Dorothee Dormann  Susanne Foitzik  Thomas Hankeln  Mark Helm  Meret Huber  Edward Lemke  Brian Luke  Helen May-Simera  Marion Silies  Lukas Stelzl  Roland Strauss  Andreas Wachter  Marie-Luise Winz  Eva Wolf  Uwe Wolfrum  Shuqing Xu  Hans Zischler 

Ciliary protein function: roles in DNA damage repair and gene regulation

Uwe Wolfrum

Research website

Positions held

  • 2006: Visiting Professor, University of Florida, Gainesville, FL
  • Since 1999: Professor, Faculty of Biology, JGU University of Mainz
  • 1994 - 1998: Assistant Professor, Cell & Neurobiology, Technical University of Karlsruhe
  • 1993 - 1994: Postdoc, Mayo Clinic Foundation, Rochester, MN
  • 1991 - 1993: Research Fellow, Cell & Neurobiology, Technical University of Karlsruhe

Education

  • 1998: Habilitation and venia legendi in Zoology, Technical University of Karlsruhe
  • 1993 - 1994: Postdoc with Dr. J.L. Salisbury, Mayo Clinic Foundation, Rochester, MN
  • 1991 - 1993: Postdoc with Prof. R. Paulsen, Cell and Neurobiology, TU Karlsruhe
  • 1988 - 1991: Dr. rer. nat. with Prof. H. Altner, University of Regensburg
  • 1988: Diploma in Biology, University of Bayreuth

Selected publications by Uwe Wolfrum

Sorusch N, Yildirim A, Knapp B, Janson J, Fleck W, Scharf C, Wolfrum U (2019) SANS (USH1G) Molecularly Links the Human Usher Syndrome Protein Network to the Intraflagellar Transport Module by Direct Binding to IFT-B Proteins. Front Cell Dev Biol, 7:216 Link

Knapp B, Roedig J, Boldt K, Krzysko J, Horn N, Ueffing M, Wolfrum U (2019) Affinity proteomics identifies novel functional modules related to adhesion GPCRs. Ann N Y Acad Sci, 1456(1):144-167 Link

Sorusch N, Bauß K, Plutniok J, Samanta A, Knapp B, Nagel-Wolfrum K, Wolfrum U (2017) Characterization of the ternary Usher syndrome SANS/ush2a/whirlin protein complex. Hum Mol Genet, 26(6):1157-1172 Link

Nagel-Wolfrum K, Möller F, Penner I, Baasov T, Wolfrum U (2016) Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs). BioDrugs, 30(2):49-74 Link

Wunderlich KA, Wolfrum U (2016) A FRAP-Based Method for Monitoring Molecular Transport in Ciliary Photoreceptor Cells In Vivo. Methods Mol Biol, 1454:97-106 Link