IPP Research Topics

Proper cell function is dependent on the proteins and other molecules in the cell being correctly folded and organised. One way cells do this is by phase separation, a physical phenomenon similar to the demixing of oil and vinegar in a vinaigrette. Phase separation is crucial for many aspects of gene regulation, such as organising RNA-protein complexes and epigenetics, as well as genome organisation and genome stability. Dysregulation of phase separation or failure to remove misfolded and damaged proteins can result in the formation of insoluble protein aggregates that contribute to neurodegenerative disease.