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At IMB, we explore the molecular biology of the nucleus with an overarching focus on gene regulation, epigenetics & genome stability

University Medical Center (UMC) Mainz

Maria Felicia Basilicata  Christian Behl  Benedikt Berninger  Luciana Berod  Tobias Bopp  Andreas Daiber  Sven Danckwardt  Carsten Deppermann  Stephan Grabbe  Thomas Hofmann  Thomas Kindler  Daniela Kramer  Daniela Krause  Dilja Krueger-Burg  Michael Kühn  Beat Lutz  Johannes Mayer  Wolfram Ruf  Susann Schweiger  Natalia Soshnikova  Tim Sparwasser  Oliver Tüscher  Sara Vieira-Silva  Ari Waisman  Philipp Wild  Jennifer Winter  Fatemeh Zare-Shahneh 

Regulation of pro-inflammatory gene expression in autoinflammatory diseases, infections and cancer

Daniela Kramer

My lab is focusing on the regulation of pro-inflammatory gene expression in autoinflammatory diseases, infections and cancer. We are trying to discover new, key molecules of inflammatory signaling pathways that become deregulated under disease conditions. The overall aim is to find small molecule inhibitors that modulate these inflammatory signaling pathways, thereby identifying new therapeutic approaches. At the moment we are focusing our research on skin and skin-related diseases, such as psoriasis, S.aureus infections and melanoma.

Our approach comprises common molecular and cell biological methods (Gene expression, RNA sequencing, lentiviral knockdown or CRISPR-Cas9 knockout), protein biochemistry (Chromatin immunoprecipitation, immunoblotting, mass spectrometry), but also the generation and analysis of various mouse models.

Research website

Positions held

  • Since 2021: Group Leader, University Medical Centre of Johannes Gutenberg University Mainz, Department of Dermatology
  • 2016 - 2021: Junior group leader, University of Tübingen, Molecular medicine
  • 2013 - 2016: Postdoctoral Researcher, University of Göttingen, Molecular Oncology

Education

  • 2012 - 2013: PhD student at GGNB Göttingen, University of Göttingen
  • 2009 - 2011: PhD student at Georg-Speyer Haus, Frankfurt a. Main
  • 2001 - 2005: MSc, HAN University of Nijmegen/St. Radboud University Nijmegen

Selected publications by Daniela Kramer

Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D (2020) The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. The Journal of clinical investigation, 130:5765–5781. Link

Lorscheid S, Müller A, Löffler J, Resch C, Bucher P, Kurschus FC, Waisman A, Schäkel K, Hailfinger S, Schulze-Osthoff K, Kramer D (2019) Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation. JCI insight, 4:e130835. Link

Müller A, Hennig A, Lorscheid S, Grondona P, Schulze-Osthoff K, Hailfinger S, Kramer D (2018) IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes. Proceedings of the National Academy of Sciences of the United States of America, 115:10088–10093. Link

Kramer D, Stark N, Schulz-Heddergott R, Erytch N, Edmunds S, Roßmann L, Bastians H, Concin N, Moll UM, Dobbelstein M (2017) Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells. Cell death and differentiation, 24:300–316. Link

Nemajerova A, Kramer D, Siller SS, Herr C, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll UM, Lizé M (2016) TAp73 is a central transcriptional regulator of airway multiciliogenesis. Genes & development, 30:1300–1312. Link