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At IMB, we explore the molecular biology of the nucleus with an overarching focus on gene regulation, epigenetics & genome stability

University Medical Center (UMC) Mainz

Maria Felicia Basilicata  Christian Behl  Benedikt Berninger  Luciana Berod  Tobias Bopp  Andreas Daiber  Sven Danckwardt  Carsten Deppermann  Stephan Grabbe  Thomas Hofmann  Thomas Kindler  Daniela Kramer  Daniela Krause  Dilja Krueger-Burg  Michael Kühn  Beat Lutz  Johannes Mayer  Wolfram Ruf  Susann Schweiger  Natalia Soshnikova  Tim Sparwasser  Oliver Tüscher  Sara Vieira-Silva  Ari Waisman  Philipp Wild  Jennifer Winter  Fatemeh Zare-Shahneh 

Systems medicine approaches to age-related diseases in humans

Philipp Wild

The Systems Medicine Group has comprehensive experience in molecular epidemiology and systems medicine research, with a focus on investigating complex common diseases, which are strongly driven by the ageing process. Our research themes include cardiovascular diseases, such as thrombotic disease and heart failure, to cardiometabolic conditions like obesity and type 2 diabetes mellitus, but also infectious diseases with system-wide sequelae (SARS-CoV-2 and COVID-19) and cancers. The study of how the ageing process induces pathological changes is highly clinically relevant and a key priority for our group.

By using artificial intelligence (AI) methods and state-of-the-art high-throughput omics profiling techniques, we holistically integrate multi-omics data with environmental exposures, (sub)clinical parameters and advanced imaging data to discover new biomarkers and biosignatures, detect diseases at an earlier stage and predict their further progression. This is the basis for the development of tailor-made therapies, diagnostics and prognostics, and therapy monitoring tools to reflect a patient’s response to therapy. A key strength of our group is our large multidisciplinary team, spanning expertise from molecular biology, biomedicine and clinical and molecular epidemiology to bioinformatics and biostatistics/AI and disciplines critical to maintaining a large clinical research infrastructure (e.g. IT, biobanking, regulatory affairs).

Research website

Positions held

  • Since 2022: PI Systems Medicine (Adjunct Clinician), Institute of Molecular Biology (IMB)
  • Since 2020: Deputy Site Speaker RheinMain, German Center for Cardiovascular Research (DZHK)
  • Since 2015: Head of Liquid Biobank, UMC, Mainz
  • Since 2015: Speaker, Research Center for Translational Vascular Biology (CTVB), UMC, Mainz
  • Since 2014: W3-Professor of Clinical Epidemiology, Center for Thrombosis and Hemostasis Mainz (CTH), UMC, Mainz
  • Since 2013: Head of Preventive Cardiology and Preventive Medicine, Center for Cardiology, UMC, Mainz
  • Since 2012: Head of Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis (CTH), UMC, Mainz
  • 2012 – 2014: W2-Professor of Clinical Epidemiology, Center for Thrombosis and Hemostasis (CTH), UMC, Mainz
  • Since 2011: Coordinating Principal Investigator and Steering Committee Member of the Gutenberg Health Study (GHS), UMC, Mainz
  • 2010 – 2012: Senior Physician, Dept. of Medicine 2, UMC, Mainz

Education

  • 2022: Board certification in Cardiology
  • 2012: MSc in Epidemiology, IMBEI, University Medical Center (UMC), Mainz
  • 2009: Board certification in Internal Medicine
  • 2004: MD, Philipps University Marburg
  • 2002: Medical School, University Leipzig and Medical School, Philipps University Marburg

Selected publications by Philipp Wild

Müller FS, Aherrahrou Z, Grasshoff H, Heidorn MW, Humrich JY, Johanson L, Aherrahrou R, Reinberger T, Schulz A, Ten Cate V, Robles AP, Koeck T, Rapp S, Lange T, Brachaczek L, Luebber F, Erdmann J, Heidecke H, Schulze-Forster K, Dechend R, Lackner KJ, Pfeiffer N, Ghaemi Kerahrodi J, Tüscher O, Schwarting A, Strauch K, Münzel T, Prochaska JH, Riemekasten G, and Wild PS (2023) Autoantibodies against the chemokine receptor 3 predict cardiovascular risk.Eur Heart J, 44:4935-4949 Link

Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G, Moll S, Panova-Noeva M, Jünger C, Eggebrecht L, Pfeiffer N, Beutel M, Binder H, Grabbe S, Lackner KJ, Ten Cate-Hoek A, Espinola-Klein C, Münzel T and Wild PS (2021) Chronic venous insufficiency, cardiovascular disease, and mortality: a population study. Eur Heart J, 42:4157-4165 Link

Ten Cate V, Prochaska JH, Schulz A, Koeck T, Pallares Robles A, Lenz M, Eggebrecht L, Rapp S, Panova-Noeva M, Ghofrani HA, Meyer FJ, Espinola-Klein C, Lackner KJ, Michal M, Schuster AK, Strauch K, Zink AM, Laux V, Heitmeier S, Konstantinides SV, Münzel T, Andrade-Navarro MA, Leineweber K and Wild PS (2021) Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism. Blood, 137:2681-2693 Link

Tröbs SO*, Prochaska JH*, Schwuchow-Thonke S, Schulz A, Müller F, Heidorn MW, Göbel S, Diestelmeier S, Lerma Monteverde J, Lackner KJ, Gori T, Münzel T and Wild PS (2021) Association of global longitudinal strain with clinical status and mortality in patients with chronic heart failure. JAMA Cardiol, 6:448-456 Link